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The efficacy of Automobile-T cells bearing a multispecific DARPin Auto for treating tumors with heterogeneous antigen expression was evaluated in vivo. Success The monospecific anti-EGFR E01 DARPin conferred potent tumor regression in opposition to EGFR+ targets that was similar having an anti-EGFR scFv CAR. Linking 3 independent DARPins in tandem
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